Biomedical Significance of Small-Animal Imaging -- Detectors for Small-Animal SPECT I -- Detectors for Small-Animal SPECT II -- The Animal in Animal Imaging -- Objective Assessment of Image Quality -- SPECT Imager Design and Data-Acquisition Systems -- Computational Algorithms in Small-Animal Imaging -- Reconstruction Algorithm with Resolution Deconvolution in a Small-Animal PET Imager -- Estimates of Axial and Transaxial Resolution for One-, Two-, and Three-Camera Helical Pinhole SPECT -- Pinhole Aperture Design for Small-Animal Imaging -- Comparison of CsI(Ti) and Scintillating Plastic in a Multi-Pinhole/CCD-Based Gamma Camera for Small-Animal Low-Energy SPECT -- Calibration of Scintillation Cameras and Pinhole SPECT Imaging Systems -- Imaging Dopamine Transporters in a Mouse Brain with Single-Pinhole SPECT -- A Micro-SPECT/CT System for Imaging of AA-Amyloidosis in Mice -- Feasibility of Micro-SPECT/CT Imaging of Atherosclerotic Plaques in a Transgenic Mouse Model -- Effect of Respiratory Motion on Plaque Imaging in the Mouse Using Tc-99m Labeled Annexin-V -- Calibration and Performance of the Fully Engineered YAP-(S)PET Scanner for Small Rodents -- A Small-Animal SPECT Imaging System Utilizing Position Tracking of Unanesthetized Mice -- A Multidetector High-Resolution SPECT/CT Scanner with Continuous Scanning Capability -- High-Resolution Multi-Pinhole Imaging Using Silicon Detectors -- Development and Characterization of a High-Resolution MicroSPECT System for Small-Animal Imaging -- High-Resolution Radionuclide Imaging Using Focusing Gamma-Ray Optics -- SPECT/Micro-CT Imaging of Bronchial Angiogenesis in a Rat -- Projection and Pinhole-Based Data Acquisition for Small-Animal SPECT Using Storage Phosphor Technology -- Cardiac Pinhole-Gated SPECT in Small Animals.Small-Animal SPECT Imaging offers a comprehensive overview of the cutting edge imaging tool that can aid in drug development, drug research, molecular imaging, and imaging science. It represents contributions of the world's leading researchers in small-animal SPECT imaging, providing coverage from the basic physics of SPECT imaging to animal studies. Important integrated sections on animal handling, image quality assessment, and reconstruction algorithms are included, allowing its audience to design and run their own studies. Key Features: Scintillation and semiconductor detector technologies Digital signal processing techniques System modeling and reconstruction algorithms Animal monitoring and handling, including anesthesia issues Applications of small-animal imaging Detailed sections on animal handling, image assessment, and reconstruction algorithms -allow readers to implement their own tailored studies Small-Animal SPECT Imaging is aimed at researchers performing imaging to study the effects of drugs, molecular agents, and treatments, including molecular imaging scientists, imaging scientists; nuclear medicine researchers, and all those interested in the application of SPECT systems in the areas of cancer research, cardiovascular research, and gene therapy About the Editors: Matthew A. Kupinski is an Assistant Professor of Optical Sciences and Radiology at the University of Arizona. He earned his Ph.D. from the University of Chicago in 2000 and joined the faculty at the University of Arizona in 2002. Harrison H. Barrett is a Regents Professor of Radiology and Optical Sciences at the University of Arizona in Tucson, Arizona. Professor Barrett joined the University of Arizona in 1974, is the former editor of the Journal of the Optical Society of America A, and is the recipient of the IEEE Medical Imaging Scientist Award in 2000. He is the coauthor of two books on image science.