Grid Generation -- Hybrid unstructured Grid Generation in MEGAFLOW -- Structured Solver FLOWer -- Block Structured Navier-Stokes Solver FLOWer -- Transition Modeling in FLOWer — Transition Prescription and Prediction -- Turbulence Models in FLOWer -- Hybrid Solver TAU -- Overview of the Hybrid RANS Code TAU -- Algorithmic Developments in TAU -- Hybrid Grid Adaptation in TAU -- Turbulence Model Implementation in TAU -- G.I.G. — A Flexible User-Interface for CFD-Code Configuration Data -- Validation -- Computation of Aerodynamic Coefficients for Transport Aircraft with MEGAFLOW -- Computation of Engine-Airframe Installation Drag -- Verification of MEGAFLOW-Software for High Lift Applications -- Shape Optimization -- The Continuous Adjoint Approach in Aerodynamic Shape Optimization -- Application of the Adjoint Technique with the Optimization Framework Synaps Pointer Pro -- Shape Parametrization Using Freeform Deformation -- Contributions of Universities -- Advanced Turbulence Modelling in Aerodynamic Flow Solvers -- Large-Eddy Simulation of Attached Airfoil Flow -- Transition Prediction for 2D and 3D Flows using the TAU-Code and N-Factor Methods -- Exploitation of MEGAFLOW Software -- Application of the MEGAFLOW Software at DLR -- MEGAFLOW for AIRBUS-D — Applications and Requirements -- Aerodynamic Analysis of Flapping Airfoil Propulsion at Low Reynolds Numbers.This volume contains results of the German CFD initiative MEGAFLOW which combines many of the CFD development activities from DLR, universities and aircraft industry. It highlights recent improvements and enhancements of the MEGAFLOW software system. This software includes the block-structured Navier-Stokes code FLOWer and the unstructured Navier-Stokes code TAU. Improvements to numerical algorithms and physical modelling capabilities of these codes are discussed. Validation activities concerning their capability to predict viscous flows around complex industrially relevant configurations for transport aircraft design are presented. The high level of maturity both codes have reached is demonstrated based on the intensive use of FLOWer and TAU by the German aerospace industry in the design process of a new aircraft.