Biochemistry, Pharmacology, and Chemistry -- Mechanism of Action of Topoisomerase 1 Poisons -- Crystallographic Insight Into the Mechanism of Drug-Induced Topoisomerase I DNA Damage -- Inhibitors of Topoisomerase I Function -- Cytotoxic Mechanisms of Topoisomerase 1 Inhibitors -- Biochemical and Genetic Analyses of DNA Topoisomerase 1-Mediated DNA Damage -- Preclinical Models for Evaluating Top…