TIR Domain-Containing Adaptors Regulate TLR Signaling Pathways -- Toll-Like Receptors: Linking Innate and Adaptive Immunity -- Activation of Insect and Vertebrate Toll Signaling: From Endogenous Cytokine Ligand to Direct Recognition of Pathogen Patterns -- Genetic Analysis of Innate Immunity: Identification and Function of the TIR Adapter Proteins -- NF-?B, an Evolutionarily Conserved Mediator …