An Overview of Phototherapy -- Optical Physics and Biotechnology -- Phototherapy Light Sources -- Quantum Description of Light Interactions with Matter -- Tissue Optics -- Photochemical Damage to Biological Systems -- Optical Methods of Imaging and Diagnosis -- Light Dosimetry Modeling for Phototherapy -- Laser Interactions with Tissues -- Photodynamic Therapy: Science and Technology -- Photody…
Historical perspective on capsaicin and its receptor -- Hot peppers, pain and analgesics -- Molecular and cellular properties of vanilloid receptors -- Structural determinants of TRPV1 functionality -- TRPV1 distribution and regulation -- Pharmacology and physiology of vanilloid receptors -- Insights into TRPV1 pharmacology provided by non-capsaicin ligands -- Endocannabinoids and vanilloid TRP…
Voltage-gated sodium channels and pain associated with nerve injury and neuropathies -- Current approaches for the discovery of novel NaV channel inhibitors for the treatment of brain disorders -- Voltage-gated sodium channels and visceral pain -- The functional interaction of accessory proteins and voltage-gated sodium channels -- Sodium channels and nociceptive nerve endings -- Signalling cas…
Nanobiotechnology for Developing Microvascular Intervention -- Importance of the Villus Microcirculation for Intestinal Absorption of Glucose -- Oxygen Transport in the Microvessel Network -- Beating-Heart Microvascular Imaging by High-Speed Video Microscope and SPring-8 -- The Laser Hot Balloon Catheter: a New Approach to Treating Atheromatous Lesions -- Design and Modification of Nanoparticle…
Chapters of general nature -- How to handle biological specimens -- Alternative specimens -- Pitfalls and cautions in analysis of drugs and poisons -- Pretreatments of human specimens -- Detection methods -- A computer system for diagnosis of causative drugs and poisons developed by the Japan Poison Information Center (Tokyo) -- Practical use of the poison-net developed by the Japan Information…
Ca2+ Chemistry, Storage and Transport in Biologic Systems -- Monitoring Intracellular Ca2+ in Brain Slices with Fluorescent Indicators -- A Brief History of Calcium Channel Discovery -- Biochemical Studies of Voltage-Gated Ca2+ Channels -- Molecular Properties of Voltage-Gated Calcium Channels -- Role of ? Subunits in Voltage-Gated Calcium Channel Functions -- Distribution and Targeting Mechani…
Membrane Proteins from Plant Viruses -- Membrane Proteins in Plant Viruses -- Structure and Function of a Viral Encoded K+ Channel -- Fusion Proteins -- HIV gp41: A Viral Membrane Fusion Machine -- Diversity of Coronavirus Spikes: Relationship to Pathogen Entry and Dissemination -- Aspects of the Fusogenic Activity of Influenza Hemagglutinin Peptides by Molecular Dynamics Simulations -- Viral I…
TLRs as bacterial sensors -- Toll-like receptors and rheumatoid arthritis: is there a connection? -- Toll-like receptor 9 and systemic autoimmune diseases -- Toll-like receptors and airway disease -- Toll-like receptors and vascular disease -- Toll-like receptors and inflammatory bowel disease -- Toll-like receptor signaling in the liver -- Toll-like receptors as key sensors of viral infection …
and historical overview -- Phytochemistry -- St. John’s Wort and its active principles in depression and anxiety — A critical analysis of receptor binding studies -- Effects on transmitter uptake and their cellular and molecular basis -- Modulation of neurotransmitter release and metabolism -- Efficacy in behavioural models of antidepressant activity -- Comparative preclinical antidepressan…
Origin, function and distribution of regulatory T cells -- History of CD25+CD4+ regulatory T cells -- “Natural” and “induced” regulatory T cells — purpose and problems associated with an emerging distinction -- The role of interleukin-10 in regulatory-T-cell suppression: reconciling the discrepancies -- Activation and distribution of regulatory T cells in naïve and antigen-stimulated…