Cancer Statistics: Some Facts -- Assessing the magnitude of the problem -- The problem is growing, not going away -- What Is Cancer? -- Cancer through the ages -- Our current understanding -- How Is Cancer Treated? -- The cancer cell-kill paradigm and its corollaries -- Chemotherapy drugs -- Treatment outcomes: Dismal by any standard -- Why Does This System Persist? -- The role of the National …
Molecular Biology and Genetics of Lung Cancer -- Angiogenesis and Lung Cancer -- Contemporary Issues in Staging of Lung Cancer -- Lung Cancer Surgery -- Radiobiology of Normal Lung Tissue and Lung Tumours -- Radiation Time, Dose, and Fractionation in the Treatment of Lung Cancer -- Treatment Planning and Conformal Radiotherpay -- Target Volumes in Non-Small Cell Lung Cancer -- Target Volumes in…
History of Adrenal Surgery -- Surgical Anatomy -- Hypothalamic-Pituitary-Adrenal Axis -- The Sympathoadrenal System -- The Value of Adrenal Imaging in Adrenal Surgery -- Cushing’s Syndrome -- Subclinical Cushing’s Syndrome -- Ectopic Cushing’s Syndrome -- Cushing’s Syndrome in Children and Adolescents -- Classic Congenital Adrenal Hyperplasia -- Overview of Mineralocorticoid Excess Synd…
The p53 Network -- The Three-Dimensional Structure of p53 -- Transcriptional Activation by p53: Mechanisms and Targeted Genes -- Transcriptional Repression by the p53 Tumor Suppressor Protein -- Posttranslational Modifications of p53: Upstream Signaling Pathways -- p53 in Human Cancer — Somatic and Inherited Mutations and Mutation-independent Mechanisms -- MDM2 and MDMX Regulators of p53 Acti…
Molecular Biology of Tumors -- Brain Tumors -- Immunophenotypic Characterization of Infiltrating Poly- and Mononuclear Cells in Childhood Brain Tumors -- Anti-Neoplastic Biological Therapies -- Experimental Therapies in Brain Tumors -- Biologic Anti-Neoplastic Therapies -- The Lymphokine Activeted Killer (LAK) Cell Phenomenon -- Angiogenesis Inhibition in Anti-Neoplastic Therapy -- Antigen Pres…
An Introduction to the Molecular Basis of Cancer -- Lung Cancer: Setting the Scene -- Genes Involved in Sporadic Forms of Lung Cancer -- Somatic Mutation in Lung Cancer -- Genetic Approaches to Studying the Association Between Smoking and Lung Cancer -- Evidence for Genetic Susceptibility to Lung Cancer Derived from Polymorphism-disease Association Studies -- Gene Expression Studies in Lung Can…
Protein Kinase Inhibitors for the Treatment of Disease: The Promise and the Problems -- General Aspects of PKs Inhibition -- New Design Strategies for Ligands That Target Protein Kinase-Mediated Protein-Protein Interactions -- Pharmacological Potential and Inhibitors of Individual Classes of Protein Kinases -- The Paullones: A Family of Pharmacological Inhibitors of Cyclin-Dependent Kinases and…
The Multiplicity of Mutations in Human Cancers -- Monitoring Chromosome Rearrangements -- Nucleotide Excision Repair and its Connection with Cancer and Ageing -- DNA Mismatch Repair and Colon Cancer -- Base Excision Repair -- Genomic Instability in Cancer Development -- Translesion Synthesis And Errorprone Polymerases -- The INK4A/Arf Network — Cell Cycle Checkpoint or Emergency Brake? -- DNA…
How CpG Island Hypermethylation Leads to Cancer Dissemination: The Sounds of Silence for Tumor and Metastasis Suppressor Genes -- A Mouse Skin Multistage Carcinogenesis Model That Unmasks Epigenetic Lesions Responsible for Metastasis -- CpG Island Hypermethylation and Lung Cancer Invasion and Metastasis -- CpG Island Hypermethylation Changes during Prostate Cancer Progression and Metastasis -- …
DNA Methylation -- Epigenetic Mechanisms of Gene Regulation -- DNA Hypo- vs. Hypermethylation in Cancer -- DNA Methylation in Urological Cancers -- DNA Methylation in Colorectal Cancer -- CpG Island Hypermethylation of Tumor Suppressor Genes in Human Cancer -- The Loss of Methyl Groups in DNA of Tumor Cells and Tissues -- Identifying Clinicopathological Association of DNA Hypermethylation in Ca…