Background and Basic Investigations -- Mechanisms of Thrombolysis -- Pathology of Cervico-Cranial Artery Occlusion -- The Ischemic Penumbra and Neuronal Salvage -- Scientific Rationale and Clinical Trials -- Preclinical Testing of Thrombolytic Therapy for Acute Ischemic Stroke -- Combination of Thrombolytic Therapy With Neuroprotectants -- Pilot and Preliminary Studies of Thrombolytic Therapy f…