Motivating Studies -- Generalized Linear Models -- Linear Mixed Models for Gaussian Longitudinal Data -- Model Families -- The Strength of Marginal Models -- Likelihood-based Marginal Models -- Generalized Estimating Equations -- Pseudo-Likelihood -- Fitting Marginal Models with SAS -- Conditional Models -- Pseudo-Likehood -- From Subject-specific to Random-effects Models -- The Generalized Lin…
Setting the Scene -- Regulatory Aspects in Using Surrogate Markers in Clinical Trials -- Notation and Motivating Studies -- The History of Surrogate Endpoint Validation -- Validation Using Single-trial Data: Mixed Binary and Continuous Outcomes -- A Meta-analytic Validation Framework for Continuous Outcomes -- The Choice of Units -- Extensions of the Meta-analytic Approach to Surrogate Endpoint…