The Basic Components of Seismo-Ionospheric Coupling -- Ionospheric Precursors of Earthquakes as they are seen from the Ground and from Space -- Near Ground and Troposphere Plasmachemistry and Electric Field -- Physics of Seismo-Ionospheric Coupling -- Main Phenomenological Features of Ionospheric Precursors of Earthquakes -- Are we Ready for Prediction? The Practical Applications -- Ultimate Re…