Overview of Geometric Data Analysis (‘Overview’) -- Correspondence Analysis -- Euclidean Cloud -- Principal Component Analysis -- Multiple Correspondence Analysis (MCA) -- Structured Data Analysis -- Stability of a Euclidean Cloud -- Inductive Data Analysis -- Research Case Studies -- Mathematical Bases.Geometric Data Analysis (GDA) is the name suggested by P. Suppes (Stanford University) t…
Setting the Scene -- Regulatory Aspects in Using Surrogate Markers in Clinical Trials -- Notation and Motivating Studies -- The History of Surrogate Endpoint Validation -- Validation Using Single-trial Data: Mixed Binary and Continuous Outcomes -- A Meta-analytic Validation Framework for Continuous Outcomes -- The Choice of Units -- Extensions of the Meta-analytic Approach to Surrogate Endpoint…
Biology in a Nutshell -- Words -- Word Distributions and Occurrences -- Physical Mapping of DNA -- Genome Rearrangements -- Sequence Alignment -- Rapid Alignment Methods: FASTA and BLAST -- DNA Sequence Assembly -- Signals in DNA -- Similarity, Distance, and Clustering -- Measuring Expression of Genome Information -- Inferring the Past: Phylogenetic Trees -- Genetic Variation in Populations -- …
Preprocessing data from genomic experiments -- Preprocessing Overview -- Preprocessing High-density Oligonucleotide Arrays -- Quality Assessment of Affymetrix GeneChip Data -- Preprocessing Two-Color Spotted Arrays -- Cell-Based Assays -- SELDI-TOF Mass Spectrometry Protein Data -- Meta-data: biological annotation and visualization -- Meta-data Resources and Tools in Bioconductor -- Querying On…
Introduction: Population Without Age -- The Life Table -- The Matrix Model Framework -- Mortality Comparisons; The Male-Female Ratio -- Fixed Regime of Mortality and Fertility: The Uses of Stable Theory -- Birth and Population Increase from the Life Table -- Birth and Population Increase from Matrix Population Models -- Reproductive Value from the Life Table -- Reproductive Value from Matrix Mo…
Matrix Preliminaries and General Linear Model -- Some General Methods for Making Inferences about Variance Components -- One-Way Classification -- Two-Way Crossed Classification without Interaction -- Two-Way Crossed Classification with Interaction -- Three-Way and Higher-Order Crossed Classifications -- Two-Way Nested Classification -- Three-Way Nested Classification -- General r-Way Nested Cl…
Inference -- Score Test: Historical Review and Recent Developments -- EM Algorithm and Optimal Censoring Schemes for Progressively Type-II Censored Bivariate Normal Data -- Inference Guided Data Exploration -- Discriminating Between Normal and Laplace Distributions -- A Simple Classification Rule for Directional Data -- Ranking and Selection -- On Some Ranking and Selection Procedures for MANOV…
Probabilistic Modeling -- A Leisurely Look at Statistical Inference -- to Learning Bayesian Networks from Data -- A Casual View of Multi-Layer Perceptrons as Probability Models -- Bioinformatics -- to Statistical Phylogenetics -- Detecting Recombination in DNA Sequence Alignments -- RNA-Based Phylogenetic Methods -- Statistical Methods in Microarray Gene Expression Data Analysis -- Inferring Ge…
Clinical Research -- Epidemiological Studies -- Health systems research -- Biochemistry-based health care research.Health research in developing countries has many facets. On one side, malaria and AIDS as main causes of morbidity and mortality are a focus for clinical and epidemiological studies. On the other side, the need for improving the health care system in general cannot be overestimated…