The Rho GTPases -- Evolution of the Human Rho GTPase Family -- Structural Analysis of Rho Protein Complexes -- Activation of GTPases by Dock180 Family of Proteins -- Rho GAPs — Regulators of Rho GTPases and More -- RhoA/C and the Actin Cytoskeleton -- Cdc42 and Rac Control of the Actin Cytoskeleton -- Regulation of Cell-Cell Adhesion by Rho Family GTPases -- Rho Proteins and Vesicle Trafficki…
The p53 Network -- The Three-Dimensional Structure of p53 -- Transcriptional Activation by p53: Mechanisms and Targeted Genes -- Transcriptional Repression by the p53 Tumor Suppressor Protein -- Posttranslational Modifications of p53: Upstream Signaling Pathways -- p53 in Human Cancer — Somatic and Inherited Mutations and Mutation-independent Mechanisms -- MDM2 and MDMX Regulators of p53 Acti…
Biology of the NPY family of peptides, their receptors and processing enzymes -- Evolutionary perspective on the NPY-PYY-PP peptides and their receptors -- Function, distribution and molecular pharmacology of NPY-family receptors -- NPY processing in neuronal and non-neuronal tissues by proconvertases -- Dipeptidyl-peptidase IV and aminopeptidase P: molecular switches of NPY/PYY receptor affini…
Diversity in Phagocytic Signaling -- Phagocytosis and Immunity -- Fc Receptor Phagocytosis -- Complement Receptors, Adhesion, and Phagocytosis -- Adding Complexity to Phagocytic Signaling: Phagocytosis-Associated Cell Responses and Phagocytic Efficiency -- Small GTP Binding Proteins and the Control of Phagocytic Uptake -- Regulation of Phagocytosis by Fc?RIIb and Phosphatases -- Phospholipases …
Molecular Biology of Tumors -- Brain Tumors -- Immunophenotypic Characterization of Infiltrating Poly- and Mononuclear Cells in Childhood Brain Tumors -- Anti-Neoplastic Biological Therapies -- Experimental Therapies in Brain Tumors -- Biologic Anti-Neoplastic Therapies -- The Lymphokine Activeted Killer (LAK) Cell Phenomenon -- Angiogenesis Inhibition in Anti-Neoplastic Therapy -- Antigen Pres…
An Introduction to the Molecular Basis of Cancer -- Lung Cancer: Setting the Scene -- Genes Involved in Sporadic Forms of Lung Cancer -- Somatic Mutation in Lung Cancer -- Genetic Approaches to Studying the Association Between Smoking and Lung Cancer -- Evidence for Genetic Susceptibility to Lung Cancer Derived from Polymorphism-disease Association Studies -- Gene Expression Studies in Lung Can…
Cancer: Clinical Challenges and Opportunities -- Gene Expression Data and Survival Analysis -- The Needed Replicates of Arrays in Microarray Experiments for Reliable Statistical Evaluation -- Pooling Information Across Different Studies and Oligonucleotide Chip Types to Identify Prognostic Genes for Lung Cancer -- Application of Survival and Meta-analysis to Gene Expression Data Combined from T…
Basic principles in physiological and pathophysiological angiogenesis -- How do endothelial cells orientate? -- New insights into intussusceptive angiogenesis -- Angiogenesis in the female reproductive system -- Arterialization, coronariogenesis and arteriogenesis -- Sprouting angiogenesis versus co-option in tumor angiogenesis -- Hormones and the neovascularization process: role of angiotensin…
Principi fondamentali della biologia molecolare -- Il genoma umano -- Espressione e regolazione genica -- Ingegneria genetica -- Tecnologie molecolari e patologie umane -- Patologie infettive -- Patologie genetiche ereditarie -- Sistema immunitario e cellule del sangue -- Il cancro -- Terapie molecolari -- Conclusioni.Ecco finalmente disponibile in italiano un testo che sin dalla sua prima ediz…
Microenvironmental Effects on Tumour Progression and Metastasis -- Role of Microenvironment on Gene Expression, Angiogenesis and Microvascular Function in Tumors -- Imaging of Angiogenesis In Vivo with Fluorescent Proteins -- The Epigenetic Influence of the Tumor Microenvironment on Melanoma Plasticity -- Dynamics of Cell Adhesion Interactions during Melanoma Development -- Matrix Metalloprotei…