History and Morphology of the Lysosome -- Transport of Lysosomal Enzymes -- Adaptor Proteins in Lysosomal Biogenesis -- Lysosomal Membrane Proteins -- Lysosomal Proteases -- Lysosomal Storage Disorders -- Lysosomal Transporters and Associated Diseases -- Neuronal Ceroid-Lipofuscinoses -- Cholesterol Transport in Lysosomes -- Therapy of Lysosomal Storage Diseases -- Lysosomal Proteome and Transc…
Pathogenesis of Kindling -- Developmental Temporal Lobe Epilepsy in Amygdala Kindled Kittens: An update -- Prenatal Betamethasone Exposure Suppresses Kindling Epileptogenesis in Immature Rats -- Development of Kindling in Immature Fast and Slow Kindling Rats -- Neonatal Heat-Induced Convulsions Affect Behaviours in Neonatal, Juvenile and Adult Rats -- Experimental Absence Versus Amygdaloid Kind…
The Central Auditory System: A Functional Analysis -- Neuronal Organization in the Inferior Colliculus -- Projections from the Cochlear Nuclear Complex to the Inferior Colliculus -- Superior Olivary Complex and Lateral Lemniscal Connections of the Auditory Midbrain -- Intrinsic and Commissural Connections of the Inferior Colliculus -- Descending Connections of the Auditory Midbrain -- The Tecto…
Discovery of the Hypocretins/Orexins and Their Receptors -- The Discovery of the Hypocretins -- Orexin and Orexin Receptors -- Animal Models in the Study of the Hypocretinergic System -- Rodent Models of Human Narcolepsy-cataplexy -- The Canine Model of Narcolepsy -- Detailed Anatomy of the Hypocretinergic System and Related Hypothalamic Circuits -- Anatomy of the Hypocretin System -- The Anato…
Gross Anatomy of the Brain -- Neurons and Associated Cells -- Basic Neurophysiology -- Blood Circulation -- Meninges, Ventricles and Cerebrospinal Fluid -- Development and Growth of the Nervous System -- The Spinal Cord -- Reflexes and Muscle Tone -- Pain and Temperature -- Discriminative General Senses, Crude Touch, and Proprioception -- Motoneurons and Motor Pathways -- Lesions of the Spinal …
General Concepts -- Glutamate Receptors in Peripheral Tissues: Distribution and Implications for Toxicology -- Glutamate Receptor Pharmacology: Lessons Learned from the Last Decade of Stroke Trials -- Expression of Non-Organelle Glutamate Transporters to Support Peripheral Tissue Function -- Anticancer Effects of Glutamate Antagonists -- Glutamate Receptors and their Role in Acute and Inflammat…
Neurodegenerative Disorders as Proteinopathies: Phenotypic Relationships -- Towards a Molecular Classification of Neurodegenerative Disease -- Racial and Ethnic Influences on the Expression of the Genotype in Neurodegenerative Diseases -- Causes and Consequences of Oxidative Stress in Neurodegenerative Diseases -- Early Onset Familial Alzheimer's Disease: Is a Mutation Predictive of Pathology? …
GPCRs: Structure and Function -- Structure—Function Relationships in G Protein-Coupled Receptors -- Molecular Mechanisms Involved in the Activation of Rhodopsin-Like Seven-Transmembrane Receptors -- GPCR Folding and Maturation -- Regulated Membrane Trafficking and Proteolysis of GPCRs -- GPCR Activity and Its Regulators -- Heterotrimeric G Proteins and Their Effector Pathways -- RGS Proteins …
Experimental Allergic (Autoimmune) Encephalomyelitis (EAE) -- EAE: History, Clinical Signs, and Disease Course -- Induction of EAE -- Histopathology of EAE -- Neuroantigens in EAE -- Adjuvants in EAE -- The Role of Astrocytes in Autoimmune Disease of the Central Nervous System -- Role of Microglia and Macrophages in Eae -- The Neuron and Axon in Experimental Autoimmune Encephalomyelitis -- Endo…
History of prevention of relapse -- How to measure relapse in animals -- How to measure relapse in humans -- Disulfiram (Antabuse®): the first medication to stop drinking -- Naltrexone: preclinical data -- Naltrexone: clinical data -- Acamprosate: preclinical data -- Acamprosate: clinical data -- Serotonergic compounds: preclinical data -- Serotonergic compounds: clinical data -- Opioidergic c…