The Multiplicity of Mutations in Human Cancers -- Monitoring Chromosome Rearrangements -- Nucleotide Excision Repair and its Connection with Cancer and Ageing -- DNA Mismatch Repair and Colon Cancer -- Base Excision Repair -- Genomic Instability in Cancer Development -- Translesion Synthesis And Errorprone Polymerases -- The INK4A/Arf Network — Cell Cycle Checkpoint or Emergency Brake? -- DNA…
How CpG Island Hypermethylation Leads to Cancer Dissemination: The Sounds of Silence for Tumor and Metastasis Suppressor Genes -- A Mouse Skin Multistage Carcinogenesis Model That Unmasks Epigenetic Lesions Responsible for Metastasis -- CpG Island Hypermethylation and Lung Cancer Invasion and Metastasis -- CpG Island Hypermethylation Changes during Prostate Cancer Progression and Metastasis -- …
DNA Methylation -- Epigenetic Mechanisms of Gene Regulation -- DNA Hypo- vs. Hypermethylation in Cancer -- DNA Methylation in Urological Cancers -- DNA Methylation in Colorectal Cancer -- CpG Island Hypermethylation of Tumor Suppressor Genes in Human Cancer -- The Loss of Methyl Groups in DNA of Tumor Cells and Tissues -- Identifying Clinicopathological Association of DNA Hypermethylation in Ca…
Clinkal Issues and Tissue Processing -- Molecular Pathology Laboratory of the Future -- Clinical Utilities of Microdissected Samples -- Tissue Processing -- Sample Management and Tracking -- Methods of Tissue Microanalysis -- Tissue Microarrays -- Molecular Analysis of Microdissected Samples -- Methods of Microdissection and New Technologies -- Standard Diagnostic Techniques -- DNA Applications…
The Hedgehog Signaling Pathway in Cancer -- Rho GTPases and Cancer -- Developmental Biology of Fibroblasts and Neoplastic Disease -- The Extracellular Matrix During Normal Development and Neoplastic Growth -- Wilms’ Tumor: Starting Off the Kidney All Over Again? -- Testicular Teratomas: Back to Pluripotent Stem Cells -- Tumor Suppressors APC and VHL: Gatekeepers of the Intestine and Kidney --…
B Cell Development and Its Deregulation to Transformed States at the Pre-B Cell Receptor-Expressing Pre-BII Cell Stage -- Gene Expression Patterns in Human and Mouse B Cell Development -- New Insights into the Phenotype and Cell Derivation of B Cell Chronic Lymphocytic Leukemia -- Chronic Lymphocytic Leukemia: Molecular Genetics and Animal Models -- What Do Somatic Hypermutation and Class Switc…
Cancer Gene Therapy -- The Genetic Basis of Cancer -- Tumor Suppressor Gene Replacement for Cancer -- Antisense Technology -- Cancer Therapeutic Applications of Ribozymes and RNAi -- Fusogeneic Membrane Glycoproteins for Cancer Gene Therapy -- Suicide Gene Therapy -- Molecular Chemotherapy Approaches -- Genetic Immunotherapy Approaches -- Immunotherapy of Cancer by Dendritic Cell-Targeted Gene …
Disfunction of the Apoptotic Pathway in Cancer Cells -- Calcium Signaling and Apoptosis Resistance of Cancer Cells -- Cell Clearance and Cancer -- Specific, Pro-Poptotic Cell-Signaling: Design of Novel, Recombinant Targeted Antitumor Agents Operating Exclusively Through Modulation of Cellular Apoptotic Events -- Targeting Oncogenes Which Regulate Apoptosis -- Targeting Cyclins to Cause Cancer C…
Apoptotic Pathways and Their Regulation -- Mechanisms of Anticancer Drug Action -- Death Receptor Pathways As Targets for Anticancer Therapy -- Caspases; Modulators of Apoptosis and Cytokine Maturation — Targets for Novel Therapies -- The Intrinsic (Mitochondrial) Death Pathway and New Cancer Therapeutics: Bcl-2 Family in Focus -- Survivin, other IAPs, Smac/Diablo, and Omi/Htra2 — Modulatio…
Monitoring Antigen-Specific T Cell Responses -- Tumor Associated Antigens -- Immune Escape, Tumor induced immune suppression and immune escape: Mechanisms and Possible Solutions -- Virus Specific T-Cell Responses -- Cytotoxicity Assays Killer Lymphocytes in Cancer -- Monitoring T Cell Proliferation -- Elispot Assay, Assessment of Cellular Immune Responses to Anti-Cancer Vaccines -- Modified Eli…