Epidemiology of Cancer and Aging -- Biological Interactions of Aging and Carcinogenesis -- Replicative Senescence and Cancer -- The Influence of Advanced Age on Cancer Occurrence and Growth -- Age and Co-Morbidity in Cancer Patients: A Population-Based Approach -- Hemopoiesis and Aging -- Clinical and Biochemical Evaluation Changes Over Aging -- Biological Screening and Impact in Elderly Cancer…
The First Twenty-Five Years of p53 Research -- Regulation of p53 DNA Binding -- 20 Years of DNA Damage Signaling to p53 -- Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX -- Regulation of the p53 Response by Cellular Growth and Survival Factors -- P53, Cell Cycle Arrest and Apoptosis -- P53 Has a Direct Pro-apoptotic Action at the Mitochondria -- Ma…
Cancer Statistics: Some Facts -- Assessing the magnitude of the problem -- The problem is growing, not going away -- What Is Cancer? -- Cancer through the ages -- Our current understanding -- How Is Cancer Treated? -- The cancer cell-kill paradigm and its corollaries -- Chemotherapy drugs -- Treatment outcomes: Dismal by any standard -- Why Does This System Persist? -- The role of the National …
Molecular Biology and Genetics of Lung Cancer -- Angiogenesis and Lung Cancer -- Contemporary Issues in Staging of Lung Cancer -- Lung Cancer Surgery -- Radiobiology of Normal Lung Tissue and Lung Tumours -- Radiation Time, Dose, and Fractionation in the Treatment of Lung Cancer -- Treatment Planning and Conformal Radiotherpay -- Target Volumes in Non-Small Cell Lung Cancer -- Target Volumes in…
History of Adrenal Surgery -- Surgical Anatomy -- Hypothalamic-Pituitary-Adrenal Axis -- The Sympathoadrenal System -- The Value of Adrenal Imaging in Adrenal Surgery -- Cushing’s Syndrome -- Subclinical Cushing’s Syndrome -- Ectopic Cushing’s Syndrome -- Cushing’s Syndrome in Children and Adolescents -- Classic Congenital Adrenal Hyperplasia -- Overview of Mineralocorticoid Excess Synd…
The p53 Network -- The Three-Dimensional Structure of p53 -- Transcriptional Activation by p53: Mechanisms and Targeted Genes -- Transcriptional Repression by the p53 Tumor Suppressor Protein -- Posttranslational Modifications of p53: Upstream Signaling Pathways -- p53 in Human Cancer — Somatic and Inherited Mutations and Mutation-independent Mechanisms -- MDM2 and MDMX Regulators of p53 Acti…
Molecular Biology of Tumors -- Brain Tumors -- Immunophenotypic Characterization of Infiltrating Poly- and Mononuclear Cells in Childhood Brain Tumors -- Anti-Neoplastic Biological Therapies -- Experimental Therapies in Brain Tumors -- Biologic Anti-Neoplastic Therapies -- The Lymphokine Activeted Killer (LAK) Cell Phenomenon -- Angiogenesis Inhibition in Anti-Neoplastic Therapy -- Antigen Pres…
An Introduction to the Molecular Basis of Cancer -- Lung Cancer: Setting the Scene -- Genes Involved in Sporadic Forms of Lung Cancer -- Somatic Mutation in Lung Cancer -- Genetic Approaches to Studying the Association Between Smoking and Lung Cancer -- Evidence for Genetic Susceptibility to Lung Cancer Derived from Polymorphism-disease Association Studies -- Gene Expression Studies in Lung Can…
Protein Kinase Inhibitors for the Treatment of Disease: The Promise and the Problems -- General Aspects of PKs Inhibition -- New Design Strategies for Ligands That Target Protein Kinase-Mediated Protein-Protein Interactions -- Pharmacological Potential and Inhibitors of Individual Classes of Protein Kinases -- The Paullones: A Family of Pharmacological Inhibitors of Cyclin-Dependent Kinases and…
The Multiplicity of Mutations in Human Cancers -- Monitoring Chromosome Rearrangements -- Nucleotide Excision Repair and its Connection with Cancer and Ageing -- DNA Mismatch Repair and Colon Cancer -- Base Excision Repair -- Genomic Instability in Cancer Development -- Translesion Synthesis And Errorprone Polymerases -- The INK4A/Arf Network — Cell Cycle Checkpoint or Emergency Brake? -- DNA…