History of prevention of relapse -- How to measure relapse in animals -- How to measure relapse in humans -- Disulfiram (Antabuse®): the first medication to stop drinking -- Naltrexone: preclinical data -- Naltrexone: clinical data -- Acamprosate: preclinical data -- Acamprosate: clinical data -- Serotonergic compounds: preclinical data -- Serotonergic compounds: clinical data -- Opioidergic c…
Drug Metabolism In Context: Introduction -- Absorption -- Drug Distribution -- Dynamics Of Drug Action -- Drug Clearance -- Dynamics Of Drug Clearance -- Pathways Of Biotransformation – Phase I Reactions: Introduction -- Phase I And Phase Ii Metabolism: General Considerations -- Oxidations Involving The Microsomal Mixed-Function Oxidase System -- Oxidations Involving Other Enzymatic Systems -…
Outside Neurons/Inside Epithelia: Novel Activation of CFTR Cl? and HCO3 ? Conductances -- Role of CFTR and Other Ion Channels in Cystic Fibrosis -- Ion Channels in the Apical Membrane: Role of Electrical Coupling on Transepithelial Transport -- Ion Channels in Secretory Granules of the Pancreas: Molecular Identification and Their Role in Regulated Secretion -- Epithelial Transport and Intracell…
Cell Cycle Activation in Neurons -- Paved with Good Intentions -- The Role of Presenilins in the Cell Cycle and Apoptosis -- Cell Cycle Activation and Cell Death in the Nervous System -- Cell Cycle and Chromosome Segregation Defects in Alzheimer’s Disease -- Alzheimer Disease -- From Cell Cycle Activation to the Inhibition of the Wnt Pathway.Cell-Cycle Mechanisms and Neuronal Cell Death exami…
to Receptor Theory -- Characterization of Receptors Based on Receptor-Mediated Responses -- Identification of Receptors Using Direct Radioligand Binding Techniques -- Complex Binding Phenomena -- The Preparation and Study of Detergent-Solubilized Receptors -- Quantifying Cell Surface Receptor Binding and Turnover in Intact Cells.Cell Surface Receptors: A Short Course on Theory and Methods, 3rd …
Cardiac Safety of Noncardiac Drugs -- Preclinical and Pharmacogenomic Cardiac Safety Evaluations -- Molecular Physiology of Ion Channels That Control Cardiac Repolarization -- Cellular, Molecular, and Pharmacologic Mechanisms Underlying Drug-Induced Cardiac Arrhythmogenesis -- hERG Assay, QT Liability, and Sudden Cardiac Death -- Pharmacogenomics in Drug Development -- Clinical Methodologies an…
Cannabis in India: ancient lore and modern medicine -- Cannabinoid chemistry: an overview -- Cannabidiol as a potential medicine -- Endocannabinoids and regulation of fertility -- Cannabinoids in neurodegeneration and neuroprotection -- Role of the endocannabinoid system in learning and memory -- Cannabinoids and anxiety -- Cannabinoid targets for pain therapeutics -- Potential use of cannabimi…
Pharmacological Actions of Cannabinoids -- Cannabinoid Receptor Signaling -- Molecular Biology of Cannabinoid Receptors -- Analysis of the Endocannabinoid System by Using CB1 Cannabinoid Receptor Knockout Mice -- The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids -- Modulators of Endocannabinoid Enzymic Hydrolysis and Membrane Transport -- Structural Requirements for Cann…
Innate and Acquired Drives -- The Conception that Whatever Humans Achieved Derives from the Unrestricted Capacity of Their Brain to Acquire Drives -- Enhancer Regulation: A Neurochemical Approach to the Innate and Acquired Drives -- Approaching Old Problems From A New Angle -- Theoretical Aspects of the Enhancer Regulation Approach -- Conclusion.The main message of this monograph is that the ap…
Protein Domain Fold Similarity and Natural Product Structure as Guiding Principles for Compound Library Design -- Sources of Polyketides and Non-Ribosomal Peptides -- Polyketide Synthases: Mechanisms and Models -- Functional and Structural Basis for Targeted Modification of Non-Ribosomal Peptlde Synthetases -- Prerequisites for Combinatorial Biosynthesis: Evolution of Hybrid NRPS/PKS Gene Clust…