Biomedical Significance of Small-Animal Imaging -- Detectors for Small-Animal SPECT I -- Detectors for Small-Animal SPECT II -- The Animal in Animal Imaging -- Objective Assessment of Image Quality -- SPECT Imager Design and Data-Acquisition Systems -- Computational Algorithms in Small-Animal Imaging -- Reconstruction Algorithm with Resolution Deconvolution in a Small-Animal PET Imager -- Estim…
An Overview of Phototherapy -- Optical Physics and Biotechnology -- Phototherapy Light Sources -- Quantum Description of Light Interactions with Matter -- Tissue Optics -- Photochemical Damage to Biological Systems -- Optical Methods of Imaging and Diagnosis -- Light Dosimetry Modeling for Phototherapy -- Laser Interactions with Tissues -- Photodynamic Therapy: Science and Technology -- Photody…
State of the Art Lectures -- Breast Cancer I: Progesterone Action -- Breast Cancer II: Mechanisms of Genomic Instability -- Early In-Situ Lesions: Breast and Prostate -- Promotion/Prevention of Hormone Cancers -- Prostate I: Androgen/Estrogen Action -- Prostate II: Androgen Receptor Dependence/Resistance -- Endometrium/Ovarian/Colon -- Communications -- Epidemiology/Human Derived Studies -- Bre…
The Discovery of Zinc Fingers and Their Practical Applications in Gene Regulation: A Personal Account -- The Discovery of Zinc Fingers and Their Practical Applications in Gene Regulation: A Personal Account -- Binding of Zinc Fingers to DNA -- C2H2 Zinc Fingers As DNA Binding Domains -- TFIIIA: A Sophisticated Zinc Finger Protein -- GAGA: Structural Basis for Single Cys2His2 Zinc Finger-DNA Int…
The First Twenty-Five Years of p53 Research -- Regulation of p53 DNA Binding -- 20 Years of DNA Damage Signaling to p53 -- Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX -- Regulation of the p53 Response by Cellular Growth and Survival Factors -- P53, Cell Cycle Arrest and Apoptosis -- P53 Has a Direct Pro-apoptotic Action at the Mitochondria -- Ma…
Cancer Statistics: Some Facts -- Assessing the magnitude of the problem -- The problem is growing, not going away -- What Is Cancer? -- Cancer through the ages -- Our current understanding -- How Is Cancer Treated? -- The cancer cell-kill paradigm and its corollaries -- Chemotherapy drugs -- Treatment outcomes: Dismal by any standard -- Why Does This System Persist? -- The role of the National …
EMT Concept and Examples from the Vertebrate Embryo -- Epithelium-Mesenchyme Transitions Are Crucial Morphogenetic Events Occurring during Early Development -- The Neural Crest -- Epithelial-Mesenchymal Transformation in the Embryonic Heart -- Epithelial-Extracellular Matrix (Cell-ECM) Interactions in Hydra -- Regulation of the Epithelial-to-Mesenchymal Transition in Sea Urchin Embryos -- Chang…
The Rho GTPases -- Evolution of the Human Rho GTPase Family -- Structural Analysis of Rho Protein Complexes -- Activation of GTPases by Dock180 Family of Proteins -- Rho GAPs — Regulators of Rho GTPases and More -- RhoA/C and the Actin Cytoskeleton -- Cdc42 and Rac Control of the Actin Cytoskeleton -- Regulation of Cell-Cell Adhesion by Rho Family GTPases -- Rho Proteins and Vesicle Trafficki…
The p53 Network -- The Three-Dimensional Structure of p53 -- Transcriptional Activation by p53: Mechanisms and Targeted Genes -- Transcriptional Repression by the p53 Tumor Suppressor Protein -- Posttranslational Modifications of p53: Upstream Signaling Pathways -- p53 in Human Cancer — Somatic and Inherited Mutations and Mutation-independent Mechanisms -- MDM2 and MDMX Regulators of p53 Acti…
Biology of the NPY family of peptides, their receptors and processing enzymes -- Evolutionary perspective on the NPY-PYY-PP peptides and their receptors -- Function, distribution and molecular pharmacology of NPY-family receptors -- NPY processing in neuronal and non-neuronal tissues by proconvertases -- Dipeptidyl-peptidase IV and aminopeptidase P: molecular switches of NPY/PYY receptor affini…