Preface -- Introduction -- Basic Concept of Ca2+ Signaling in Cells and Tissues (M. J. Sanderson) -- Modeling IP-3-Dependent Calcium Dynamics in Non-Excitable Cells (J. Sneyd) -- Integrated Calcium Management in Cardiac Myocytes (T. R. Shannon) -- Mechanisms and Models of Cardiac Excitation-Contraction Coupling (R. L. Winslow, R. Hinch, J. L. Greenstein) -- Mathematical Analysis of the Generati…
Historical perspective on capsaicin and its receptor -- Hot peppers, pain and analgesics -- Molecular and cellular properties of vanilloid receptors -- Structural determinants of TRPV1 functionality -- TRPV1 distribution and regulation -- Pharmacology and physiology of vanilloid receptors -- Insights into TRPV1 pharmacology provided by non-capsaicin ligands -- Endocannabinoids and vanilloid TRP…
Voltage-gated sodium channels and pain associated with nerve injury and neuropathies -- Current approaches for the discovery of novel NaV channel inhibitors for the treatment of brain disorders -- Voltage-gated sodium channels and visceral pain -- The functional interaction of accessory proteins and voltage-gated sodium channels -- Sodium channels and nociceptive nerve endings -- Signalling cas…
The Human OXPHOS System -- Molecular Biology of the OXPHOS System -- Clinical Diagnosis of Oxidative Phosphorylation Disorders -- Contribution of Histopathological Examination to the Diagnosis of OXPHOS Disorders -- Biochemical Diagnosis of OXPHOS Disorders -- Mitochondrial DNA and OXPHOS Disorders -- Nuclear DNA and Oxidative Phosphorylation -- Cell Biological Consequences of OXPHOS Disorders …
Rice Genome Sequencing and Data Mining Resources -- Application of Evolutionary Computation to Bioinformatics -- Architectures for Integration of Data and Applications -- Functional Genomics Approach to Elucidate the Regulation of Vascular Development in Poplar -- Novel Tools for Plant Genome Annotation and Applications to Arabidopsis and Rice -- FCModeler -- Old Methods for New Ideas: Genetic …
Oligonucleotides as Radiopharmaceuticals -- Imaging Protein-Protein Interactions in Whole Cells and Living Animals -- Radiolabeled Peptides in Nuclear Oncology: Influence of Peptide Structure and Labeling Strategy on Pharmacology -- Pretargeted Radioimmunotherapy -- PET/CT: Combining Function and Morphology -- High Relaxivity Contrast Agents for MRI and Molecular Imaging -- Luminescent Lanthani…
The Control Layer -- Exploring Protein Structure and Function -- Macromolecular Forces -- Protein Folding and Binding -- Stress and Pheromone Responses in Yeast -- Two-Component Signaling Systems -- Organization of Signal Complexes by Lipids, Calcium, and Cyclic AMP -- Signaling by Cells of the Immune System -- Cell Adhesion and Motility -- Signaling in the Endocrine System -- Signaling in the …
State of the Art Lectures -- Breast Cancer I: Progesterone Action -- Breast Cancer II: Mechanisms of Genomic Instability -- Early In-Situ Lesions: Breast and Prostate -- Promotion/Prevention of Hormone Cancers -- Prostate I: Androgen/Estrogen Action -- Prostate II: Androgen Receptor Dependence/Resistance -- Endometrium/Ovarian/Colon -- Communications -- Epidemiology/Human Derived Studies -- Bre…
The Discovery of Zinc Fingers and Their Practical Applications in Gene Regulation: A Personal Account -- The Discovery of Zinc Fingers and Their Practical Applications in Gene Regulation: A Personal Account -- Binding of Zinc Fingers to DNA -- C2H2 Zinc Fingers As DNA Binding Domains -- TFIIIA: A Sophisticated Zinc Finger Protein -- GAGA: Structural Basis for Single Cys2His2 Zinc Finger-DNA Int…
Ca2+ Chemistry, Storage and Transport in Biologic Systems -- Monitoring Intracellular Ca2+ in Brain Slices with Fluorescent Indicators -- A Brief History of Calcium Channel Discovery -- Biochemical Studies of Voltage-Gated Ca2+ Channels -- Molecular Properties of Voltage-Gated Calcium Channels -- Role of ? Subunits in Voltage-Gated Calcium Channel Functions -- Distribution and Targeting Mechani…