Historical perspective on capsaicin and its receptor -- Hot peppers, pain and analgesics -- Molecular and cellular properties of vanilloid receptors -- Structural determinants of TRPV1 functionality -- TRPV1 distribution and regulation -- Pharmacology and physiology of vanilloid receptors -- Insights into TRPV1 pharmacology provided by non-capsaicin ligands -- Endocannabinoids and vanilloid TRP…
Voltage-gated sodium channels and pain associated with nerve injury and neuropathies -- Current approaches for the discovery of novel NaV channel inhibitors for the treatment of brain disorders -- Voltage-gated sodium channels and visceral pain -- The functional interaction of accessory proteins and voltage-gated sodium channels -- Sodium channels and nociceptive nerve endings -- Signalling cas…
Headache for History Buffs -- When Is a Headache More Than “Just a Headache?”: The Secondary Headaches -- The Primary Headache Syndromes: When Is a Headache “Just a Headache?” -- The Pharmacologic Treatment of Migraine -- Nonpharmacologic Treatment of Migraine -- Your Visit to the Doctor -- What to Expect.Frequent headaches seriously affect the lives of millions of sufferers. The result…
The discovery, development and novel actions of nimesulide -- Pharmacokinetics of nimesulide -- Pharmaceutical formulations of nimesulide -- Pharmacological properties of nimesulide -- Clinical applications of nimesulide in pain, arthritic conditions and fever -- Adverse reactions and their mechanisms from nimesulide.Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a c…
Sections/Topics -- 1 The human and humanitarian challenge of suffering (This topic includes philosophical and practical perspectives, the global geography of suffering and its relief, social solidarity, social responsibility for relief of suffering, collective action, empathic altruism, and interpersonal caring.) -- 2 Quality of Life (QOL) research challenges (The topic includes issues such as …